What I like so far
I have just finished building a site using Atomz Publish, a web based content management system, that isn't too far from what CityDesk is (it's template based). The one thing I hated about it is solved with CityDesk...it's a native app so I can use keyboard commands. You know, that nifty ctl+s...you really start to miss it on a web app. It doesn't seem like that much until you don't have it.
A very minor thing in relative terms, but from a diminishing overall stress levels standpoint, toweringly impressive:
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